Have you considered adding a zone system?
If you are living in a two story home with a single heating and cooling system with the thermostat downstairs, I be you are experiencing temperature differences of about 5-8 degrees between the upstairs and the downstairs rooms. A zone system may just be your solution. And with new products on the market from all the major thermostat manufacturers, it is getting easier every day. The new WiFi thermostats mean you do not have to run wires through existing walls. The zone board can be connected to a WiFi transmitter right near the equipment and then you can mount the thermostats in just about any room you would want. Now the upstairs can be controlled independently from the downstairs so there is not more running up and down the stairs to adjust the temperatures.
Below is the Honeywell RedLink WiFi zone system.
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